Camptothecin

【Botanical】: Camptotheca acuminata Decne

【Appearance】: Light Yellow powder.
【Specification】98% by HPLC

【Molecular Formula】: C₂₀H₁₆N₂O₄

【Molecular Weight】: 348.36

【CAS Number】: 7689-03-4

【Actions】: Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

Baoji Herbest Co., Ltd as a leading manufacture of herbal extracts in China. specialized in the provision of high-purity pharmaceutical ingredient separation and purification technological solutions.

We supply

Chlorogenic acid 98%.cryptochlorogenic acid; neochlorogenic acid; Isochlorogenic acid

Hesperidin 98%

Andrographolide

Daidzein

Resveratol

Tanshinone IIA

Puerarin 99%

Hypericin

Rutin 98%

Sodium Aescinate

Paeoniflorm

Tetrahydropalmatine

GinkgolideA;B;C

Gardenoside

Ginsenoside Rb1;Rb2;Rb3,Rg1,Rg2,Rg3;Rh1;Rh2;Rh3;Rf,Rf11;Rc;Re;Rd

SaikosaponinA;C;D

Costundide; Dehydrocostus Lactone.

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